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Article

E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury.

Nature medicine - 1 Aug 2007

Bachmaier Kurt, Toya Sophie, Gao Xiaopei, Triantafillou Thomas, Garrean Sean, Park Gye Young, Frey Randall S, Vogel Stephen, Minshall Richard, Christman John W, Tiruppathi Chinnaswamy, Malik Asrar B

Abstract excerpt

The E3 ubiquitin ligase Cblb has a crucial role in the prevention of chronic inflammation and autoimmunity. Here we show that Cblb also has an unexpected function in acute lung inflammation. Cblb attenuates the sequestration of inflammatory cells in the lungs after administration of lipopolysacch...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17618294
DOI: 10.1038/nm1607

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17618294-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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