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Article

Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2007

Schwartzkopff Sabrina, Gründemann Carsten, Schweier Oliver, Rosshart Stephan, Karjalainen Klaus Erik, Becker Karl-Friedrich, Pircher Hanspeter

Abstract excerpt

The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK cells and memory T cells in man and mice. Cadherins were recently identified as ligands for mouse KLRG1 but ligands for human KLRG1 have not yet been defined. In this study, we first demonstrate that human E-cadherin is a ligand for human KLRG1. This finding is remarkable because human and mouse KLRG1 show only an intermediate degree of homology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17617594
DOI: 10.4049/jimmunol.179.2.1022

Genes

KLRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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