Article
Interaction of KLRG1 with E-cadherin: new functional and structural insights.
European journal of immunology - 1 Dec 2008
Rosshart Stephan, Hofmann Maike, Schweier Oliver, Pfaff Anne-Kathrin, Yoshimoto Keiko, Takeuchi Tsutomu, Molnar Eszter, Schamel Wolfgang W, Pircher Hanspeter
Abstract excerpt
The killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed by memory T cells and NK cells in man and mice. It is frequently used as a cell differentiation marker and members of the cadherin family are ligands for KLRG1. The present study provides new insights into the interaction of mouse KLRG1 with E-cadherin. Firstly, we demonstrate that co-engagement of KLRG1 and CD3/TCR in a spatially...
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