Article
Expression, Function, and Molecular Properties of the Killer Receptor Ncr1-Noé.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2015
Glasner Ariella, Simic Hrvoje, Miklić Karmela, Roth Ziv, Berhani Orit, Khalaila Isam, Jonjic Stipan, Mandelboim Ofer
Abstract excerpt
NK cells kill various cells using activating receptors, such as the natural cytotoxicity receptors (NCRs). NKp46 is a major NCR and is the only NCR expressed in mice (denoted Ncr1). Using Ncr1-deficient mice (Ncr1(gfp/pfp)) we demonstrated that Ncr1 controls various pathologies, and that in its absence Ncr1-related functions are impaired. In 2012, another Ncr1-related mouse was generated, named Noé, in which a...
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