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Article

Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2008

Bozza Silvia, Zelante Teresa, Moretti Silvia, Bonifazi Pierluigi, DeLuca Antonella, D'Angelo Carmen, Giovannini Gloria, Garlanda Cecilia, Boon Louis, Bistoni Francesco, Puccetti Paolo, Mantovani Alberto, Romani Luigina

Abstract excerpt

TLRs contribute to the inflammatory response in fungal infections. Although inflammation is an essential component of the protective response to fungi, its dysregulation may significantly worsen fungal diseases. In this study, we tested the hypothesis that Toll IL-1R8 (TIR8)/single Ig IL-1-related receptor, a member of the IL-1R family acting as a negative regulator of TLR/IL-1R signaling, affects TLR responses...

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PMID: 18322211
DOI: 10.4049/jimmunol.180.6.4022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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