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Article

Toll-interacting Protein Modulates Colitis Susceptibility in Mice

26 Feb 2014

Abstract excerpt

BACKGROUND: The intestinal epithelium accommodates with a myriad of commensals to maintain immunological homeostasis, but the underlying mechanisms regulating epithelial responsiveness to flora-derived signals remain poorly understood. Herein, we sought to determine the role of the Toll/interleukin (IL)-1 receptor regulator Toll-interacting protein (Tollip) in intestinal homeostasis. METHODS: Colitis...

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PMID: 24572204
DOI: 10.1097/mib.0000000000000006

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