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SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and Repair

1 Oct 1996

Abstract excerpt

Mutators are cells that have a higher mutation rate than the wild type. Such mutators have been extensively studied in bacteria, and this has led to the elucidation of a number of important DNA repair pathways, as well as revealing new pathways of mutagenesis. Repair defects in humans that lead to mutator phenotypes are responsible for a number of cancer susceptibilities. In some cases, these repair systems are...

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PMID: 8905093
DOI: 10.1146/annurev.micro.50.1.625

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