Article
Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine:guanine mispair to prevent spontaneous G:C-->C:G transversions.
Nucleic acids research - 15 Oct 1998
Zhang Q M, Ishikawa N, Nakahara T, Yonei S
Abstract excerpt
Low rates of spontaneous G:C-->C:G transversions would be achieved not only by the correction of base mismatches during DNA replication but also by the prevention and removal of oxidative base damage in DNA. Escherichia coli must have several pathways to repair such mismatches and DNA modificatio...
Topics
- Base Pair Mismatch
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- DNA Glycosylases
- DNA Mutational Analysis
- DNA Repair
- Escherichia coli
- Genes, Reporter
- Guanine
- Mutagenesis, Insertional
- N-Glycosyl Hydrolases
- Oligonucleotides
- Phenotype
- Recombinant Fusion Proteins
- Sequence Analysis, DNA