Article
Molecular classification of sporadic Creutzfeldt-Jakob disease.
Brain : a journal of neurology - 1 Jun 2003
Hill Andrew F, Joiner Susan, Wadsworth Jonathan D F, Sidle Katie C L, Bell Jeanne E, Budka Herbert, Ironside James W, Collinge John
Abstract excerpt
According to the protein-only hypothesis of prion propagation, an abnormal isoform (designated PrP(Sc)) of the cellular prion protein (PrP(C)) is the principal or sole component of transmissible prions. However, the existence of multiple prion strains has been difficult to accommodate within this hypothesis. We have previously reported the identification of four types of human PrP(Sc) associated with sporadic and...
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