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Article

Co-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selection.

The Journal of biological chemistry - 11 Oct 2013

Haldiman Tracy, Kim Chae, Cohen Yvonne, Chen Wei, Blevins Janis, Qing Liuting, Cohen Mark L, Langeveld Jan, Telling Glenn C, Kong Qingzhong, Safar Jiri G

Abstract excerpt

The unique phenotypic characteristics of mammalian prions are thought to be encoded in the conformation of pathogenic prion proteins (PrP(Sc)). The molecular mechanism responsible for the adaptation, mutation, and evolution of prions observed in cloned cells and upon crossing the species barrier...

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Share to Adaptation, Physiological
Share to Blotting, Western
Share to Creutzfeldt-Jakob Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoassay

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Share to Protein Stability

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Share to Selection, Genetic

Source

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Identifiers

PMID: 23974118
DOI: 10.1074/jbc.M113.500108
PMCID: PMC3795283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23974118-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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