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Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

8 Dec 1998

Abstract excerpt

We have designed a p53 DNA binding domain that has virtually the same binding affinity for the gadd45 promoter as does wild-type protein but is considerably more stable. The design strategy was based on molecular evolution of the protein domain. Naturally occurring amino acid substitutions were identified by comparing the sequences of p53 homologues from 23 species, introducing them into wild-type human p53, and...

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PMID: 9843948
DOI: 10.1073/pnas.95.25.14675

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