Article
Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population.
Psychiatry and clinical neurosciences - 1 Aug 2007
Watanabe Yuichiro, Nunokawa Ayako, Kaneko Naoshi, Muratake Tatsuyuki, Koizumi Masataka, Someya Toshiyuki
Abstract excerpt
Interleukin-1 (IL1) is an inflammatory cytokine and exerts neurodegenerative effects in the brain. Several studies have indicated that IL1 is likely to be involved in the pathogenesis of schizophrenia. Recent genetic studies have revealed that the IL1 gene complex (IL,1 alpha, IL1, beta and IL1 receptor antagonist) was associated with schizophrenia, although contradictory findings have also been reported. To...
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