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Interleukin 1 beta gene and risk of schizophrenia: detailed case-control and family-based studies and an updated meta-analysis.

Human psychopharmacology - 1 Jan 2014

Shibuya Masako, Watanabe Yuichiro, Nunokawa Ayako, Egawa Jun, Kaneko Naoshi, Igeta Hirofumi, Someya Toshiyuki

Abstract excerpt

OBJECTIVE: Interleukin-1 beta (IL-1β) has been implicated in the pathophysiology of schizophrenia. To assess whether the IL1B gene confers increased susceptibility to schizophrenia, we conducted case-control and family-based studies and an updated meta-analysis. METHODS: We tested the association between IL1B and schizophrenia in 1229 case-control and 112 trio samples using 12 markers, including common tagging...

Topics

Adult
Case-Control Studies
Female
Genetic Predisposition to Disease
Humans
Interleukin-1beta
Male
Middle Aged
Polymorphism, Single Nucleotide
Schizophrenia
Young Adult

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PMID: 24155145
DOI: 10.1002/hup.2365

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