Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR Cells

5 Nov 2014

Abstract excerpt

PURPOSE: P-glycoprotein mediated efflux is one of the main mechanisms for multidrug resistance in cancers, and 3-Bromopyruvate acts as a promising multidrug resistance reversal compound in our study. To test the ability of 3-Bromopyruvate to overcome P-glycoprotein-mediated multidrug resistance and to explore its mechanisms of multidrug resistance reversal in MCF-7/ADR cells, we evaluate the in vitro and in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Metal complexes synthesis and properties
Share to Nanoparticle-Based Drug Delivery

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25372840
DOI: 10.1371/journal.pone.0112132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR CellsPMID 25372840Read ↗

Discovery of Dihydropyrrol-2-ones as Novel G0/G1-Phase Arresting Agents Inducing ApoptosisSemantic proximity Read ↗

Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR).Semantic proximity Read ↗

A novel compound RY10-4 downregulates P-glycoprotein expression and reverses multidrug-resistant phenotype in human breast cancer MCF-7/ADR cells.Semantic proximity Read ↗

The role of phytochemicals in modulating breast cancer resistance protein at the blood-brain barrier and the blood-tumour barrierSemantic proximity Read ↗

A multidrug resistance transporter from human MCF-7 breast cancer cellsSemantic proximity Read ↗

The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer CellsSemantic proximity Read ↗

The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expressionSemantic proximity Read ↗

Discovering Natural Product Modulators to Overcome Multidrug Resistance in Cancer ChemotherapySemantic proximity Read ↗

11a-N-Tosyl-5-deoxi-pterocarpan, LQB-223, a novel compound with potent antineoplastic activity toward breast cancer cells with different phenotypes.Semantic proximity Read ↗

Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma CellsSemantic proximity Read ↗

Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression.Semantic proximity Read ↗

Half-sandwich Os( ii ) and Ru( ii ) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.