Article
Modulatory effect of tamoxifen and ICI 182,780 on adriamycin resistance in MCF-7 human breast-cancer cells.
International journal of cancer - 4 Nov 1996
De Vincenzo R, Scambia G, Benedetti Panici P, Fattorossi A, Bonanno G, Ferlini C, Isola G, Pernisco S, Mancuso S
Abstract excerpt
In this study the ability of the new pure anti-estrogen ICI 182,780 to modulate the cytotoxic action of adriamycin (ADR) on parental and ADR-resistant MCF-7 (MCF-7 ADRr) human breast-cancer cells was investigated and compared with that of tamoxifen (TAM). TAM enhanced ADR cytotoxicity in MCF-7 AD...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibiotics, Antineoplastic
- Antibodies, Monoclonal
- Antibody Specificity
- Antineoplastic Agents
- Breast Neoplasms
- Cell Cycle
- DNA, Neoplasm
- Doxorubicin
- Drug Resistance, Multiple