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Article

Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293 cells.

British journal of pharmacology - 1 Sept 2007

Shi J, Takahashi S, Jin X-H, Li Y-Q, Ito Y, Mori Y, Inoue R

Abstract excerpt

BACKGROUND AND PURPOSE: Myosin light chain kinase (MLCK) plays a pivotal role in regulation of cellular functions, the evidence often relying on the effects of extracelluarly administered drugs such as ML-9. Here we report that this compound exerts non-specific inhibitory actions on the TRPC6 channel, a transient receptor potential (TRP) protein. EXPERIMENTAL APPROACH: Macroscopic and single channel currents were...

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Identifiers

PMID: 17603544
DOI: 10.1038/sj.bjp.0707368
PMCID: PMC1978268

Genes

TRPC6
TRPC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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