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Article

Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6.

The Journal of physiology - 1 Sept 2008

Takahashi Shinichi, Lin Hai, Geshi Naomi, Mori Yasuo, Kawarabayashi Yasuhiro, Takami Noboru, Mori Masayuki X, Honda Akira, Inoue Ryuji

Abstract excerpt

We investigated the inhibitory role of the nitric oxide (NO)-cGMP-protein kinase G (PKG) pathway on receptor-activated TRPC6 channels in both a heterologous expression system (HEK293 cells) and A7r5 vascular myocytes. Cationic currents due to TRPC6 expression were strongly suppressed (by approxim...

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Share to Cyclic GMP
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18617565
DOI: 10.1113/jphysiol.2008.156083
PMCID: PMC2652196

Genes

TRPC6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18617565-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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