Article
CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels.
Biochemical and biophysical research communications - 14 Jul 2006
Gao Lei, Blair Leslie A C, Marshall John
Abstract excerpt
Widely regarded as a specific and potent inhibitor of CaM kinases, especially CaMKII, KN93 has long been used to investigate the possible roles of CaMKII in a wide range of biological functions and systems, such as cultured cells, primary neurons, and brain slices. However, here we present evidence showing that KN93 and its structural analog KN92, which does not inhibit CaMKII, exert an unexpected, reversible,...
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