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Article

Riluzole activates TRPC5 channels independently of PLC activity.

British journal of pharmacology - 1 Jan 2014

Richter Julia M, Schaefer Michael, Hill Kerstin

Abstract excerpt

BACKGROUND AND PURPOSE: The transient receptor potential channel C5 (TRPC5) is a Ca(2+)-permeable cation channel, which is predominantly expressed in the brain. TRPC5 is activated in a PLC-dependent manner by, as yet, unidentified endogenous messengers. Recently, modulators of TRPC5, like Ca(2+), pH and phospholipids, have been identified. However, the role of TRPC5 in vivo is only poorly understood. Novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24117252
DOI: 10.1111/bph.12436
PMCID: PMC3874704

Genes

TRPC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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