Article
Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide.
American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2009
Ihara Eikichi, Moffat Lori, Borman Meredith A, Amon Jennifer E, Walsh Michael P, MacDonald Justin A
Abstract excerpt
As a regulator of smooth muscle contraction, zipper-interacting protein kinase (ZIPK) can directly phosphorylate the myosin regulatory light chains (LC20) and produce contractile force. Synthetic peptides (SM-1 and AV25) derived from the autoinhibitory region of smooth muscle myosin light chain k...
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