Article
Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase.
The Journal of biological chemistry - 9 Mar 2001
Moral Z, Dong K, Wei Y, Sterling H, Deng H, Ali S, Gu R, Huang X Y, Hebert S C, Giebisch G, Wang W H
Abstract excerpt
We have used the two-electrode voltage clamp technique and the patch clamp technique to investigate the regulation of ROMK1 channels by protein-tyrosine phosphatase (PTP) and protein-tyrosine kinase (PTK) in oocytes coexpressing ROMK1 and cSrc. Western blot analysis detected the presence of the endogenous PTP-1D isoform in the oocytes. Addition of phenylarsine oxide (PAO), an inhibitor of PTP, reversibly reduced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.