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Article

Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter?

American journal of physiology. Cell physiology - 1 Jul 2005

Di Ciano-Oliveira Caterina, Lodyga Monika, Fan Lingzhi, Szászi Katalin, Hosoya Hiroshi, Rotstein Ori D, Kapus András

Abstract excerpt

Myosin light-chain (MLC) kinase (MLCK)-dependent increase in MLC phosphorylation has been proposed to be a key mediator of the hyperosmotic activation of the Na+-K+-2Cl- cotransporter (NKCC). To address this hypothesis and to assess whether MLC phosphorylation plays a signaling or permissive role in NKCC regulation, we used pharmacological and genetic means to manipulate MLCK, MLC phosphorylation, or myosin...

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PMID: 15728707
DOI: 10.1152/ajpcell.00631.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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