Article
CYP3A4 and MDR1 alleles in a Portuguese population.
Clinical chemistry and laboratory medicine - 1 Oct 2003
Cavaco Isa, Gil J Pedro, Gil-Berglund Eva, Ribeiro Vera
Abstract excerpt
Polymorphisms in cytochrome P450 CYP3A4 and multidrug resistance (MDR) 1 genes coding for the important drug-metabolising CYP3A4 and the ATP-binding cassette (ABC) transporter P-glycoprotein (Pgp) are poorly documented in the Portuguese population. In this study we have determined the frequencies of CYP3A4 and MDR1 alleles in Portuguese Caucasians. Both genes were simultaneously analysed as these genes are known...
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