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Article

Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism.

The pharmacogenomics journal - 1 Aug 2008

Rodríguez-Antona C, Niemi M, Backman J T, Kajosaari L I, Neuvonen P J, Robledo M, Ingelman-Sundberg M

Abstract excerpt

Cytochrome P450 2C8 (CYP2C8) plays a major role in the metabolism of therapeutically important drugs which exhibit large interindividual differences in their pharmacokinetics. In order to evaluate any genetic influence on this variation, a CYP2C8 phenotype-genotype evaluation was carried out in Caucasians. Two novel CYP2C8 haplotypes, named B and C with frequencies of 24 and 22% in Caucasians, respectively, were...

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Identifiers

PMID: 17923851
DOI: 10.1038/sj.tpj.6500482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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