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Article

Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle.

Journal of cell science - 1 Apr 2004

Nongthomba Upendra, Clark Sam, Cummins Mark, Ansari Maqsood, Stark Meg, Sparrow John C

Abstract excerpt

Myofibrillar proteins assemble to form the highly ordered repetitive contractile structural unit known as a sarcomere. Studies of myogenesis in vertebrate cell culture and embryonic developmental systems have identified some of the processes involved during sarcomere formation. However, isoform changes during vertebrate muscle development and a lack of mutants have made it difficult to determine how these...

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Identifiers

PMID: 15075240
DOI: 10.1242/jcs.01024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle.PMID 15075240Read ↗

A cis-regulatory mutation in troponin-I of Drosophila reveals the importance of proper stoichiometry of structural proteins during muscle assembly.Semantic proximity Read ↗

Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities.Semantic proximity Read ↗

Bruno 1 regulates cytoskeleton dynamics and a temporal splicing transition to promote myofibril assembly, growth and maturation in <i>Drosophila</i> flight muscleSemantic proximity Read ↗

Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight muscles.Semantic proximity Read ↗

Abnormal muscle development in the heldup3 mutant of Drosophila melanogaster is caused by a splicing defect affecting selected troponin I isoforms.Semantic proximity Read ↗

Mutations in Drosophila myosin rod cause defects in myofibril assembly.Semantic proximity Read ↗

Specific myosin heavy chain mutations suppress troponin I defects in Drosophila muscles.Semantic proximity Read ↗

Effect of myonuclear number and mitochondrial fusion on Drosophila indirect flight muscle organization and size.Semantic proximity Read ↗

Aberrant splicing of an alternative exon in the Drosophila troponin-T gene affects flight muscle development.Semantic proximity Read ↗

Flightless I and LRRFIP work together to regulate lateral growth of the sarcomeres in <i>Drosophila</i>Semantic proximity Read ↗

Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly in Drosophila flight musclesSemantic proximity Read ↗

A genetic approach to detect muscle protein interactions in vivo.Semantic proximity Read ↗

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