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Article

LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.

Development (Cambridge, England) - 1 Nov 2005

Shaye Daniel D, Greenwald Iva

Abstract excerpt

A novel mode of crosstalk between the EGFR-Ras-MAPK and LIN-12/Notch pathways occurs during the patterning of a row of vulval precursor cells (VPCs) in Caenorhabditis elegans: activation of the EGFR-Ras-MAPK pathway in the central VPC promotes endocytosis and degradation of LIN-12 protein. LIN-12 downregulation in the central VPC is a prerequisite for the activity of the lateral signal, which activates LIN-12 in...

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Identifiers

PMID: 16236769
DOI: 10.1242/dev.02076

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.PMID 16236769Read ↗

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The AGEF-1/ARF-1 GTPase/AP-1 trafficking pathway differentially regulates LIN-12/Notch signaling in a tissue specific manner in <i>C. elegans</i>Semantic proximity Read ↗

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