Caenorhabditis elegans atx-2 Promotes Germline Proliferation and the Oocyte FateSequence data from this article have been deposited with the EMBL/GenBank Data Libraries under accession no. AY571963.

Abstract excerpt

In the Caenorhabditis elegans germline, proliferation is induced by Notch-type signaling. Entry of germ cells into meiosis is triggered by activity of the GLD-1 and GLD-2 pathways, which function redundantly to promote meiosis and/or inhibit proliferation. Activation of the germline Notch-type receptor, GLP-1, ultimately inhibits the activities of the GLD-1 and GLD-2 pathways. We previously identified several ego...

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