Article
Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?
Mechanisms of ageing and development - 30 Sept 2001
Rajagopalan S, Andersen J K
Abstract excerpt
Protein aggregation appears to be the common denominator in a series of distinct neurodegenerative diseases yet its role in the associated neuronal pathology in these various conditions remains elusive. In Parkinson's disease, localization of alpha synuclein aggregates within intracellular Lewy body occlusions represent a major hallmark of this disorder and suggest that such aggregation may play a causative role...
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