Article

Mathematical modeling of the role of α-synuclein and dopamine in cell death in Parkinson’s disease provides the molecular basis to the toxicity of different point mutations

2019-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Different types of α-synuclein and non-β-amyloid component (NAC) peptides have been shown to induce cell death, with varying degree of toxicity, in various in vitro experiments. Oxidative stress has also been associated and proved to be involved in the pathogenesis of neuronal cell death in Parkinson’s disease. Oxidative stress has been shown to accelerate the aggregation of α-synuclein in vitro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2ea00d0-9385-533b-8b8d-9439d2034d11
DOI: 10.1101/714600

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mathematical modeling of the role of α-synuclein and dopamine in cell death in Parkinson’s disease provides the molecular basis to the toxicity of different point mutationsDOI 10.1101/714600Read

Cell systems and the toxic mechanism(s) of alpha-synuclein.Semantic proximity Read

[Free radicals and ailing proteins--the culprits behind Parkinson disease?].Semantic proximity Read

Formal model of Parkinson’s disease neurons unveils possible causality links in the pathophysiology of the diseaseSemantic proximity Read

[Cellular pathophysiology of Parkinson's disease].Semantic proximity Read

[Dopaminergic neuronal death in Parkinson's disease: is accumulation of unfolded proteins a cause or effect?].Semantic proximity Read

Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease.Semantic proximity Read

[Parkinson disease: mechanisms of cell death].Semantic proximity Read

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cellsSemantic proximity Read

Cellular models to investigate biochemical pathways in Parkinson's disease.Semantic proximity Read

Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's DiseaseSemantic proximity Read

Advancing Parkinson’s Disease Biopathlogy and Drug Discovery by Dual Cellular ModelingSemantic proximity Read

The pathogenesis of cell death in Parkinson's disease – 2007Semantic proximity Read