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Article

Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis.

Carcinogenesis - 1 Jun 2017

Hamada Shin, Taguchi Keiko, Masamune Atsushi, Yamamoto Masayuki, Shimosegawa Tooru

Abstract excerpt

The Keap1-Nrf2 system contributes to the maintenance of homeostasis by regulating oxidative stress responses in normal tissues and organs, and is exploited in various cancers for proliferation, survival and acquisition of therapy resistance. Pancreatic cancer remains one of the intractable cancers, despite the improved clinical outcomes of other types of cancer, due to its invasive and refractory nature to...

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PMID: 29240881
DOI: 10.1093/carcin/bgx043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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