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Article

Integrin beta3 Leu33Pro polymorphism and risk of hip fracture: 25 years follow-up of 9233 adults from the general population.

Pharmacogenetics and genomics - 1 Jan 2007

Tofteng Charlotte L, Bach-Mortensen Pernille, Bojesen Stig E, Tybjaerg-Hansen Anne, Hyldstrup Lars, Nordestgaard Børge G

Abstract excerpt

OBJECTIVE: Integrin alphavbeta3 is essential for mature osteoclast function and therefore important for the development of osteoporosis and osteoporotic fractures. Integrin alphavbeta3 antagonists have antiresorptive effects in bone. We tested the hypothesis that the Leu33Pro polymorphism in the integrin beta3-subunit associates with risk of hip fracture. METHODS: We included 9233 men and women selected at random...

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PMID: 17264806
DOI: 10.1097/01.fpc.0000236327.80809.f8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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