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Article

Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia.

Stroke - 1 Aug 2007

Hoppe Carolyn, Klitz William, D'Harlingue Katherine, Cheng Suzanne, Grow Michael, Steiner Lori, Noble Janelle, Adams Robert, Styles Lori

Abstract excerpt

BACKGROUND AND PURPOSE: The etiology of stroke in children with sickle cell anemia (SCA) is complex and poorly understood. Growing evidence suggests that genetic factors beyond the sickle cell mutation influence stroke risk in SCA. We previously reported risk associations with polymorphisms in several proinflammatory genes in SCA children with ischemic stroke. The aim of this replication study was to confirm our...

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Source

Identifiers

PMID: 17600229
DOI: 10.1161/STROKEAHA.107.483115

Genes

TNF
ADRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia.PMID 17600229Read ↗

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