Article
Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1.
American journal of hematology - 1 Feb 2011
Dworkis Daniel A, Klings Elizabeth S, Solovieff Nadia, Li Guihua, Milton Jacqueline N, Hartley Stephen W, Melista Efthymia, Parente Jason, Sebastiani Paola, Steinberg Martin H, Baldwin Clinton T
Abstract excerpt
Sickle cell anemia (SCA, HBB glu6val) is characterized by multiple complications and a high degree of phenotypic variability: some subjects have only sporadic pain crises and few acute hospitalizations, while others experience multiple serious complications, high levels of morbidity, and accelerated mortality [1]. The tumor necrosis factor-α (TNF-α) signaling pathway plays important roles in inflammation and the...
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