Article
Genetic predictors for stroke in children with sickle cell anemia.
Blood - 16 Jun 2011
Flanagan Jonathan M, Frohlich Denise M, Howard Thad A, Schultz William H, Driscoll Catherine, Nagasubramanian Ramamoorthy, Mortier Nicole A, Kimble Amy C, Aygun Banu, Adams Robert J, Helms Ronald W, Ware Russell E
Abstract excerpt
Stroke is a devastating complication of sickle cell anemia (SCA), affecting 5% to 10% of patients before adulthood. Several candidate genetic polymorphisms have been proposed to affect stroke risk, but few have been validated, mainly because previous studies were hampered by relatively small sample sizes and the absence of additional patient cohorts for validation testing. To verify the accuracy of proposed...
Topics
- Adolescent
- Anemia, Sickle Cell
- Child
- Child, Preschool
- Cohort Studies
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Glucosephosphate Dehydrogenase
- Glucosephosphate Dehydrogenase Deficiency
- Humans
- Male
- Polymorphism, Single Nucleotide