Article
Distinct HLA associations by stroke subtype in children with sickle cell anemia.
Blood - 1 Apr 2003
Hoppe Carolyn, Klitz William, Noble Janelle, Vigil Lara, Vichinsky Elliott, Styles Lori
Abstract excerpt
Children with sickle cell anemia (SCA) carry a 200-fold increased risk for cerebral infarction. Stroke can be the result of small-vessel (SV) or large-vessel (LV) disease. However, it is unknown whether these subtypes result from the same pathophysiologic processes. Complete HLA genotyping was performed on 231 eligible children previously enrolled in the Cooperative Study of Sickle Cell Disease (CSSCD). Cerebral...
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