Article
Mammary cancer resistance and precocious mammary differentiation in the WKY rat: identification of 2 quantitative trait loci.
International journal of cancer - 15 Oct 2007
Lella Virginie, Stieber Daniel, Rivière Michèle, Szpirer Josiane, Szpirer Claude
Abstract excerpt
The COP and WKY rat strains are resistant to mammary cancer. It has shown previously that upon chemical carcinogen treatment, COP females exhibit mammary preneoplastic lesions which disappear within a few weeks. We show here that in similar conditions, WKY females do not exhibit any visible preneoplastic lesions. WKY females are characterized by precocious mammary tissue differentiation, including active...
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