Overcoming the activity of mammary carcinoma suppressor gene in Copenhagen rats by v-H-ras oncogene transfer into mammary epithelial cells in situ.

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Article

Overcoming the activity of mammary carcinoma suppressor gene in Copenhagen rats by v-H-ras oncogene transfer into mammary epithelial cells in situ.

Cancer research - 1 Oct 1991

Wang B, Kennan W S, Yasukawa-Barnes J, Lindstrom M J, Gould M N

Abstract excerpt

Susceptibility to mammary cancer in rats is genetically controlled by both susceptibility and suppressor genes. The Copenhagen (COP) rat strain is highly resistant to both spontaneous and induced mammary carcinogenesis. The resistant trait is due to the inheritance of an autosomal dominant allele termed mammary carcinoma suppressor (mcs) gene. To test whether the activity of mcs gene can suppress the transforming...

Topics

Animals
Blotting, Northern
Blotting, Southern
Cell Transformation, Neoplastic
Chromosome Mapping
Genes, Tumor Suppressor
Genes, ras
Genetic Predisposition to Disease
Glucocorticoids
Mammary Neoplasms, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Transplantation

Prolactin

Rats

Rats, Inbred Strains

Retroviridae

Transfection

Source

Open in PubMed

Identifiers

PMID: 1913652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1913652-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Overcoming the activity of mammary carcinoma suppressor gene in Copenhagen rats by v-H-ras oncogene transfer into mammary epithelial cells in situ.PMID 1913652Read ↗

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