Article
Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas.
Diseases of the colon and rectum - 1 Nov 2004
Okawa Takuya, Yoshinaga Keigo, Uetake Hiroyuki, Sato Takanobu, Higuchi Tetsuro, Nemoto Tetsuo, Sugihara Kenichi
Abstract excerpt
PURPOSE: Cyclooxygenase-2 is thought to play a role in the development of intestinal tumors and levels are elevated in approximately 80 to 90 percent of human colorectal carcinomas. To clarify the role that cyclooxygenase-2 plays in the development of colorectal carcinoma, we studied the relationship between cyclooxygenase-2 expression and tumor morphology and that between cyclooxygenase-2 expression and K-ras...
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