Article
Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian adenocarcinomas.
International journal of oncology - 1 Jan 2003
Shigemasa Kazushi, Tian Xiurong, Gu Lijun, Shiroyama Yuko, Nagai Nobutaka, Ohama Koso
Abstract excerpt
To investigate cyclooxygenase-2 (COX-2) expression and its relationship to p53 accumulation in ovarian adenocarcinomas, COX-2 and p53 protein expressions were examined by immunohistochemistry in 86 ovarian adenocarcinomas and six normal ovaries. In addition, COX-2 mRNA expression level was examined by semi-quantitative PCR in 36 ovarian adenocarcinomas. Neither COX-2 expression nor p53 accumulation were detected...
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