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Article

State dependent dissociation of HERG channel inhibitors.

British journal of pharmacology - 1 Aug 2007

Stork D, Timin E N, Berjukow S, Huber C, Hohaus A, Auer M, Hering S

Abstract excerpt

BACKGROUND AND PURPOSE: Inhibition of HERG channels prolongs the ventricular action potential and the QT interval with the risk of torsade de pointes arrhythmias and sudden cardiac death. Many drugs induce greater inhibition of HERG channels when the cell membrane is depolarized frequently. The dependence of inhibition on the pulsing rate may yield different IC(50) values at different frequencies and thus affect...

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Identifiers

PMID: 17592502
DOI: 10.1038/sj.bjp.0707356
PMCID: PMC2189824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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State dependent dissociation of HERG channel inhibitors.PMID 17592502Read ↗

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