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Article

Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.

British journal of pharmacology - 1 Mar 2006

Kawakami Kazunobu, Nagatomo Toshihisa, Abe Haruhiko, Kikuchi Kan, Takemasa Hiroko, Anson Blake D, Delisle Brian P, January Craig T, Nakashima Yasuhide

Abstract excerpt

beta-Blockers are widely used in the treatment of cardiovascular diseases. However, their effects on HERG channels at comparable conditions remain to be defined. We investigated the direct acute effects of beta-blockers on HERG current and the molecular basis of drug binding to HERG channels with mutations of putative common binding site (Y652A and F656C). beta-Blockers were selected based on the receptor...

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Identifiers

PMID: 16314852
DOI: 10.1038/sj.bjp.0706508
PMCID: PMC1751343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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