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Article

Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic mice.

Journal of cell science - 1 Jul 2007

Fischer Andreas, Stuckas Heiko, Gluth Markus, Russell Tanya D, Rudolph Michael C, Beeman Neal E, Bachmann Sebastian, Umemura Shinobu, Ohashi Yasuhiro, Neville Margaret C, Theuring Franz

Abstract excerpt

The mammary gland undergoes a complex set of changes to establish copious milk secretion at parturition. To test the hypothesis that signaling through the Rho pathway plays a role in secretory activation, transgenic mice expressing a constitutively activated form of the Rho effector protein PKN1 in the mammary epithelium were generated. PKN1 activation had no effect in late pregnancy but inhibited milk secretion...

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Topics

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Share to Glucocorticoids
Share to Mammary Glands, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Transforming Growth Factor beta3

Share to Zonula Occludens-1 Protein

Source

Identifiers

PMID: 17591691
DOI: 10.1242/jcs.03467

Genes

PKN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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