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Article

Generation of myometrium-specific Bmal1 knockout mice for parturition analysis

6 Jan 2012

Abstract excerpt

Human and rodent studies indicate a role for circadian rhythmicity and associated clock gene expression in supporting normal parturition. The importance of clock gene expression in tissues besides the suprachiasmatic nucleus is emerging. Here, a Bmal1 conditional knockout mouse line and a novel Cre transgenic mouse line were used to examine the role of myometrial Bmal1 in parturition. Ninety-two percent (22/24)...

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PMID: 22697126
DOI: 10.1071/rd11164

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