Article
Characterization of mutations in the VP(1) region of Sabin strain type 1 polioviruses isolated from vaccine-associated paralytic poliomyelitis cases in Iran.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Aug 2007
Rahimi Pooneh, Tabatabaie H, Gouya Mohammad M, Zahraie Mohsen, Mahmudi M, Ziaie A, Rad K Samimi, Shahmahmudi Sh, Musavi T, Azad T Mokhtari, Nategh R
Abstract excerpt
BACKGROUND: The live-attenuated oral polio vaccine used to interrupt poliovirus transmission is genetically unstable. Reversion of some attenuating mutations, which normally occurs during vaccine strain replication in some recipients, and can rarely cause vaccine-associated paralytic poliomyelitis (VAPP). The poliovirus eradication program designed by the World Health Organization (WHO) includes immunization with...
Topics
- Adult
- Amino Acid Substitution
- Capsid Proteins
- Female
- Humans
- Iran
- Male
- Middle Aged
- Muscle Hypotonia
- Mutation