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Article

Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice.

PloS one - 1 Jan 2015

Yu Tian, Taussig Matthew D, DiPatrizio Nicholas V, Astarita Giuseppe, Piomelli Daniele, Bergman Bryan C, Dell'Acqua Mark L, Eckel Robert H, Wang Hong

Abstract excerpt

Alterations in lipid metabolism have been found in several neurodegenerative disorders, including Alzheimer's disease. Lipoprotein lipase (LPL) hydrolyzes triacylglycerides in lipoproteins and regulates lipid metabolism in multiple organs and tissues, including the central nervous system (CNS). Though many brain regions express LPL, the functions of this lipase in the CNS remain largely unknown. We developed mice...

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Source

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Identifiers

PMID: 26263173
DOI: 10.1371/journal.pone.0135113
PMCID: PMC4532501

Genes

LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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