Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells.

Nature genetics - 1 Mar 2000

Chen Y, Yee D, Dains K, Chatterjee A, Cavalcoli J, Schneider E, Om J, Woychik R P, Magnuson T

Abstract excerpt

The ability to generate mutations is a prerequisite to functional genetic analysis. Despite a long history of using mice as a model system for genetic analysis, the scientific community has not generated a comprehensive collection of multiple alleles for most mouse genes. The chemical mutagen of choice for mouse has been N-ethyl-N-nitrosourea (ENU), an alkylating agent that mainly causes base substitutions in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chimera
Share to Codon
Share to Ethylnitrosourea

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypoxanthine Phosphoribosyltransferase

Share to Mutagens

Share to O(6)-Methylguanine-DNA Methyltransferase

Share to RNA Splicing

Share to Stem Cells

Source

Identifiers

PMID: 10700191
DOI: 10.1038/73557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells.PMID 10700191Read ↗

Mouse mutagenesis-systematic studies of mammalian gene function.Semantic proximity Read ↗

An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells.Semantic proximity Read ↗

Genomewide two-generation screens for recessive mutations by ES cell mutagenesis.Semantic proximity Read ↗

Mutagenesis strategies for identifying novel loci associated with disease phenotypes.Semantic proximity Read ↗

Mouse models of genetic disease: new approaches, new paradigms.Semantic proximity Read ↗

Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.Semantic proximity Read ↗

Mouse ENU mutagenesis.Semantic proximity Read ↗

ENU mutagenesis, a way forward to understand gene function.Semantic proximity Read ↗

Using ENU mutagenesis for phenotype-driven analysis of the mouse.Semantic proximity Read ↗

ENU mutagenesis in the mouse: application to human genetic disease.Semantic proximity Read ↗

ENU-induced phenovariance in mice: inferences from 587 mutations.Semantic proximity Read ↗

Genome-wide analysis of chemically induced mutations in mouse in phenotype-driven screens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.