Melanomagenesis: Overcoming the barrier of melanocyte senescence

Abstract excerpt

Although melanoma ultimately progresses to a highly aggressive and metastatic disease that is typically resistant to currently available therapy, it often begins as a benign nevus consisting of a clonal population of hyperplastic melanocytes that cannot progress because they are locked in a state of cellular senescence. Once senescence is overcome, the nevus can exhibit dysplastic features and readily progress to...

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• Share to Advanced biosensing and bioanalysis techniques
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