Article

Developmental-stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors

2018-06-26

Abstract excerpt

Most retinoblastomas initiate in response to the inactivation of the RB1 gene and loss of functional RB protein. The tumors may form without additional genomic changes and develop after a pre-malignant retinoma phase. Despite this seemingly straightforward etiology, mouse models have not recapitulated the genetic, cellular, and stage-specific features of human retinoblastoma genesis. For example, whereas human re...

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Literature Corpus work: a9915785-fb5e-587c-a59c-cb937998ed99
DOI: 10.1101/356527

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