Article

Structure-Guided Design and Dynamic Evaluation of VP4-Targeting siRNAs Against Rotavirus A

2026-04-04

Abstract excerpt

Rotavirus is a major cause of severe diarrheal disease in children under the age of five, with reduced vaccine effectiveness in low-resource settings causing substantial morbidity and mortality. In the absence of approved antiviral therapeutics, treatment is largely supportive, urging the need for targeted and precision-based interventions. VP4 protein plays an essential role in viral attachment, entry, and infect...

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Literature Corpus work: 03e3b67a-962a-5982-8281-fc74dba4e59e
DOI: 10.64898/2026.04.03.716385

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