Article
DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations.
Nucleic acids research - 1 Jan 2007
Hoffmann Christian, Minkah Nana, Leipzig Jeremy, Wang Gary, Arens Max Q, Tebas Pablo, Bushman Frederic D
Abstract excerpt
Treatment of HIV-infected individuals with antiretroviral agents selects for drug-resistant mutants, resulting in frequent treatment failures. Although the major antiretroviral resistance mutations are routinely characterized by DNA sequencing, treatment failures are still common, probably in part because undetected rare resistance mutations facilitate viral escape. Here we combined DNA bar coding and massively...
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